{"id":248,"date":"2017-09-27T20:02:17","date_gmt":"2017-09-27T11:02:17","guid":{"rendered":"http:\/\/neg.bacura.jp\/?p=248"},"modified":"2018-09-22T07:33:48","modified_gmt":"2018-09-21T22:33:48","slug":"%e3%82%84%e3%81%9b%e8%96%ac%e3%81%bf%e3%81%9f%e3%81%84%e3%81%aa%e5%a4%a2%e3%81%ae%e3%81%82%e3%82%8b%e8%a9%b1%e3%81%af%e5%a5%bd%e3%81%8d%e3%82%88","status":"publish","type":"post","link":"https:\/\/bacura.jp\/?p=248","title":{"rendered":"\u3084\u305b\u85ac\u307f\u305f\u3044\u306a\u5922\u306e\u3042\u308b\u8a71\u306f\u597d\u304d\u3088"},"content":{"rendered":"<p>\u4e0d\u8001\u9577\u5bff\u307e\u3067\u3044\u304f\u3068\u300c\u3044\u3084\u3044\u3084\u3044\u3084\u7121\u7406\u3063\u3057\u3087\u300d\u3068\u601d\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u304c\u3001\u697d\u3057\u3066\u75e9\u305b\u308b\u304f\u3089\u3044\u306a\u3089\u300c\u30de\u30b8\u304b\u3088\uff01\uff01\u300d\u3068\u98df\u3044\u3064\u3044\u3066\u3057\u307e\u3046\u306e\u304c\u4eba\u306e\u6027\u3002\u30cd\u30c3\u30c8\u3092\u5f77\u5fa8\u3063\u3066\u3044\u308b\u3068\u305f\u307e\u306b\u305d\u3093\u306a\u30cb\u30e5\u30fc\u30b9\u306b\u51fa\u304f\u308f\u3057\u307e\u3059\u3002\u305b\u3063\u304b\u304f\u8208\u5473\u3092\u6301\u3063\u305f\u3066\u98df\u3044\u3064\u3044\u305f\u4e8b\u67c4\u306a\u306e\u3067\u3001\u3061\u3083\u3093\u3068\u5480\u56bc\u3057\u3066\u77e5\u8b58\u3068\u3057\u3066\u84c4\u7a4d\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u3053\u308d\u3067\u3059\u3002<\/p>\n<p>\u5b9f\u969b\u306e\u30cb\u30e5\u30fc\u30b9\u306f\u6c7a\u3057\u3066\u697d\u3057\u3066\u75e9\u305b\u308b\u65b9\u6cd5\u3067\u306f\u306a\u304f\u3066\u3001\u898b\u51fa\u3057\u3068\u3057\u3066\u306f\u300c\u8102\u80aa\u3092\u305f\u3060\u8caf\u8535\u3059\u308b\u767d\u8272\u8102\u80aa\u7d30\u80de\u3092\u8102\u80aa\u3092\u71c3\u713c\u3057\u3066\u71b1\u3092\u7523\u751f\u3059\u308b\u8102\u80aa\u7d30\u80de\u306b\u3059\u308b\u65b9\u6cd5\u3092\u898b\u3064\u3051\u305f\u305c\u300d\u3068\u304b\u305d\u3093\u306a\u611f\u3058\u3002\u5143\u3005\u306e\u8ad6\u6587\u306e\u30bf\u30a4\u30c8\u30eb\u306f\u300cPexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression\u300d\u3067PexRAP\u3068\u8a00\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u306fPRDM1\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u304c\u4ed5\u5207\u3063\u3066\u308b\u71b1\u7523\u751f\u95a2\u9023\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u6291\u5236\u3057\u307e\u3059\u3088\u300d\u3068\u3044\u3046\u611f\u3058\u3067\u3001\u3061\u3087\u3063\u3068\u30cb\u30e5\u30a2\u30f3\u30b9\u304c\u9055\u3046\u3068\u3044\u3046\u304b\u75e9\u305b\u308b\u3053\u3068\u306b\u5bfe\u3059\u308b\u30d1\u30c3\u30b7\u30e7\u30f3\u304c\u6e1b\u3063\u3066\u307e\u3059\u3002<\/p>\n<p><a href=\"http:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(17)31219-6\">http:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(17)31219-6<\/a><\/p>\n<p>\u7814\u7a76\u5185\u5bb9\u3068\u3057\u3066\u306f\u524d\u304b\u3089\u602a\u3057\u3044\u3068\u601d\u3063\u3066\u305fPexRAP\u3092\u3076\u3063\u58ca\u3057\u305f\u30cd\u30ba\u30df\u3092\u4f5c\u3063\u305f\u3089\u3001\u8102\u80aa\u3092\u84c4\u7a4d\u3059\u308b\u767d\u8272\u8102\u80aa\u7d30\u80de\u304c\u5c11\u306a\u304f\u3066\u8102\u80aa\u306e\u84c4\u7a4d\u3082\u5c11\u306a\u304f\u3066\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u304c\u591a\u3044\u5c0f\u3055\u306a\u30cd\u30ba\u30df\u306b\u306a\u308a\u307e\u3057\u305f\u3002PRDM16\u306f\u672c\u6c17\u51fa\u3057\u305f\u3089\u71b1\u751f\u7523\u306b\u5fc5\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u7fa4\u3092\u767a\u73fe\u3055\u305b\u308b\u306e\u3067\u3001\u767d\u8272\u8102\u80aa\u7d30\u80de\u306b\u71b1\u7523\u751f\u80fd\u529b\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u3067\u3082PexRAP\u304c\u90aa\u9b54\u3057\u3066\u308b\u306e\u3067\u7121\u7406\u3067\u3059\u3088\u3068\u3002<\/p>\n<p><a href=\"http:\/\/neg.bacura.jp\/wp-content\/uploads\/2017\/09\/IMGP0181.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-252\" src=\"http:\/\/neg.bacura.jp\/wp-content\/uploads\/2017\/09\/IMGP0181-595x274.png\" alt=\"\" width=\"595\" height=\"274\" srcset=\"https:\/\/bacura.jp\/wp-content\/uploads\/2017\/09\/IMGP0181-595x274.png 595w, https:\/\/bacura.jp\/wp-content\/uploads\/2017\/09\/IMGP0181-768x354.png 768w, https:\/\/bacura.jp\/wp-content\/uploads\/2017\/09\/IMGP0181-960x442.png 960w, https:\/\/bacura.jp\/wp-content\/uploads\/2017\/09\/IMGP0181.png 1446w\" sizes=\"auto, (max-width: 595px) 100vw, 595px\" \/><\/a><\/p>\n<p>\u306a\u306e\u3067\u3001PexRAP\u304c\u50cd\u304b\u306a\u3044\u3088\u3046\u85ac\u3092\u4f5c\u308c\u3070\u3001\u98f2\u3080\u3060\u3051\u3067\u52dd\u624b\u306b\u30ac\u30f3\u30ac\u30f3\u8102\u80aa\u304c\u71c3\u3084\u3055\u308c\u3066\u75e9\u305b\u3061\u3083\u3046\u3088\u3002\u5922\u306e\u3088\u3046\u306a\u8a71\u30e4\u30c3\u30bf\u30fc\u3001\u3066\u306a\u3082\u3093\u3067\u3059\u3088\u3002<\/p>\n<p>\u307e\u3041\u5b9f\u969b\u3001\u305d\u3046\u3044\u3046\u85ac\u304c\u51fa\u6765\u305f\u3068\u3057\u3066\u305d\u3046\u7c21\u5358\u306b\u306f\u3044\u304b\u306a\u3044\u3093\u3067\u3059\u3051\u3069\u306d\u3002\u307e\u305a\u3001\u3053\u306ePexRAP\u306f\u3069\u3053\u306b\u3042\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u8102\u80aa\u7d30\u80de\u3060\u3051\u304b\u306a\uff1f\u3068\u3044\u3046\u308f\u3051\u3067\u3001THE\u3000PROTEIN\u3000ATLAS\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u5e03\u304c\u5206\u304b\u30b5\u30a4\u30c8\u3067\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n<p><a href=\"https:\/\/www.proteinatlas.org\">https:\/\/www.proteinatlas.org<\/a><\/p>\n<p><a href=\"http:\/\/neg.bacura.jp\/wp-content\/uploads\/2017\/09\/SnapCrab_NoName_2017-9-27_19-44-52_No-00.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-254\" src=\"http:\/\/neg.bacura.jp\/wp-content\/uploads\/2017\/09\/SnapCrab_NoName_2017-9-27_19-44-52_No-00-595x536.png\" alt=\"\" width=\"595\" height=\"536\" srcset=\"https:\/\/bacura.jp\/wp-content\/uploads\/2017\/09\/SnapCrab_NoName_2017-9-27_19-44-52_No-00-595x536.png 595w, https:\/\/bacura.jp\/wp-content\/uploads\/2017\/09\/SnapCrab_NoName_2017-9-27_19-44-52_No-00-768x692.png 768w, https:\/\/bacura.jp\/wp-content\/uploads\/2017\/09\/SnapCrab_NoName_2017-9-27_19-44-52_No-00.png 904w\" sizes=\"auto, (max-width: 595px) 100vw, 595px\" \/><\/a><\/p>\n<p>\u3042\u30fc\u3001\u5168\u3066\u306e\u7d44\u7e54\u3067\u30ac\u30c3\u30c1\u30ea\u767a\u73fe\u3057\u3066\u307e\u3059\u306d\u3002\u3068\u8a00\u3046\u3053\u3068\u306f\u7d50\u69cb\u666e\u904d\u7684\u306a\u7d30\u80de\u6a5f\u80fd\u3092\u62c5\u3063\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u306d\u3002\u3053\u306e\u50cd\u304d\u3092\u6b62\u3081\u305f\u3089\u8272\u3093\u306a\u3068\u3053\u308d\u306b\u5f71\u97ff\u3067\u305d\u3046\u3067\u3059\u306d\u3002\u3060\u3044\u305f\u3044\u3001\u5c0f\u3055\u3044\u30cd\u30ba\u30df\u304c\u51fa\u6765\u307e\u3057\u305f\u3063\u3066\u3069\u308c\u304f\u3089\u3044\u304b\u3068\u3044\u3046\u3068\u901a\u5e38\u306e1\/3\u4ee5\u4e0b\u3063\u3066\u3001\u305d\u308c\u306f\u3082\u3046\u75e9\u305b\u3066\u308b\u3068\u3044\u3046\u30ec\u30d9\u30eb\u3058\u3083\u306a\u3044\u3057\u3001\u660e\u3089\u304b\u306b\u767a\u9054\u969c\u5bb3\u304c\u51fa\u3066\u308b\u3002\u3042\u3046\u30fc\u3002<\/p>\n<p>\u3067\u3082\u3001\u8ae6\u3081\u3066\u306f\u3044\u3051\u307e\u305b\u3093\u3002\u4e16\u306e\u4e2d\u306b\u306f\u5fae\u5c0f\u91dd\u304c\u3064\u3044\u305f\u30d1\u30c3\u30c1\u3067\u8868\u76ae\u304b\u3089\u76f4\u63a5\u8102\u80aa\u7d44\u7e54\u306b\u85ac\u3092\u3076\u3061\u8fbc\u3093\u3067\u3001\u767d\u8272\u8102\u80aa\u7d30\u80de\u306b\u71b1\u7523\u751f\u80fd\u529b\u3092\u4e0e\u3048\u3066\u75e9\u305b\u3088\u3046\u305c\u3002\u307f\u305f\u3044\u306a\u3053\u3068\u3092\u3084\u3063\u3066\u308b\u4eba\u305f\u3061\u3082\u3044\u308b\u306e\u3067\u3001\u6c17\u9577\u306b\u5f85\u3061\u307e\u3057\u3087\u3046\u3002\u4eca\u306e\u3068\u3053\u308d\u5168\u90e8\u30cd\u30ba\u30df\u306e\u8a71\u3067\u3059\u3051\u3069\u306d\u3002<\/p>\n<p><a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acsnano.7b04348\">http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acsnano.7b04348<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0d\u8001\u9577\u5bff\u307e\u3067\u3044\u304f\u3068\u300c\u3044\u3084\u3044\u3084\u3044\u3084\u7121\u7406\u3063\u3057\u3087\u300d\u3068\u601d\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u304c\u3001\u697d\u3057\u3066\u75e9\u305b\u308b\u304f\u3089\u3044\u306a\u3089\u300c\u30de\u30b8\u304b\u3088\uff01\uff01\u300d\u3068\u98df\u3044\u3064\u3044\u3066\u3057\u307e\u3046\u306e\u304c\u4eba\u306e\u6027\u3002\u30cd\u30c3\u30c8\u3092\u5f77\u5fa8\u3063\u3066\u3044\u308b\u3068\u305f\u307e\u306b\u305d\u3093\u306a\u30cb\u30e5\u30fc\u30b9\u306b\u51fa\u304f\u308f\u3057\u307e\u3059\u3002\u305b\u3063\u304b\u304f\u8208\u5473\u3092\u6301\u3063\u305f\u3066\u98df\u3044 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":253,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_crdt_document":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-248","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-chat"],"_links":{"self":[{"href":"https:\/\/bacura.jp\/index.php?rest_route=\/wp\/v2\/posts\/248","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bacura.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bacura.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bacura.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bacura.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=248"}],"version-history":[{"count":4,"href":"https:\/\/bacura.jp\/index.php?rest_route=\/wp\/v2\/posts\/248\/revisions"}],"predecessor-version":[{"id":366,"href":"https:\/\/bacura.jp\/index.php?rest_route=\/wp\/v2\/posts\/248\/revisions\/366"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bacura.jp\/index.php?rest_route=\/wp\/v2\/media\/253"}],"wp:attachment":[{"href":"https:\/\/bacura.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=248"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bacura.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=248"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bacura.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=248"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}